Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 49,000 | |||
25 mg | 在庫あり | ¥ 106,500 | |||
50 mg | 在庫あり | ¥ 153,500 | |||
100 mg | 在庫あり | ¥ 214,000 | |||
500 mg | 在庫あり | ¥ 427,000 |
説明 | PU139 is a novel inhibitor of histone acetyltransferase (HAT). |
ターゲット&IC50 | PCAF:9.74 μM (IC50), p300:5.35 μM (IC50), GCN5:8.39 μM (IC50), CBP:2.49 μM (IC50) |
In vitro | PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HCT116, HepG2, SW480, U-87 MG and SK-N-SH and MCF7 cells). PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1]. |
In vivo | PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1]. |
別名 | PU 139, PU-139 |
分子量 | 246.26 |
分子式 | C12H7FN2OS |
CAS No. | 158093-65-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (40.61 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PU139 158093-65-3 Chromatin/Epigenetic Histone Acetyltransferase PU 139 PU-139 Inhibitor inhibitor inhibit