Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 21,000 | |||
10 mg | 在庫あり | ¥ 30,500 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 83,000 | |||
100 mg | 在庫あり | ¥ 124,000 |
説明 | Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. |
In vitro | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
In vivo | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
動物実験 | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
別名 | PK-8165 hydrochloride |
分子量 | 352.9 |
分子式 | C22H25ClN2 |
CAS No. | 80221-58-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: >30 mg/mL (94.8 mM)
You can also refer to dose conversion for different animals. 詳細
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Pipequaline hydrochloride 80221-58-5 Membrane transporter/Ion channel Neuroscience GABA Receptor inhibit Gamma-aminobutyric acid Receptor Pipequaline Hydrochloride PK-8165 hydrochloride PK-8165 PK8165 Pipequaline PK 8165 PK 8165 Hydrochloride Inhibitor PK8165 Hydrochloride γ-Aminobutyric acid Receptor PK-8165 Hydrochloride inhibitor