Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
説明 | Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
In vitro | In guinea pigs, Prednisolone significantly reduces the partial pressure of oxygen in the pleural lining (PL-oxygen tension). In rats, Prednisolone (5 mg/kg) induces diaphragm contraction and histological alterations, resulting in an increased number of diaphragm bundles. |
In vivo | In quadriceps and soleus muscles, Prednisolone (0.75 mg/kg) is effective in reducing the populations of macrophages, CD4(+) T cells, CD8+ T cells, and eosinophils. At a dosage of 50 mg/kg, Prednisolone suppresses the levels of mRNA for NOS stimulated by lipopolysaccharides in neutrophils of mice. Furthermore, Prednisolone mediates its anti-inflammatory effects by decreasing the expression of cell adhesion molecules. |
別名 | Predonine, Hydroretrocortine, Metacortandralone |
分子量 | 360.44 |
分子式 | C21H28O5 |
CAS No. | 50-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL (27.74 mM)
DMSO: 45 mg/mL (124.85 mM)
You can also refer to dose conversion for different animals. 詳細
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Prednisolone 50-24-8 Endocrinology/Hormones Metabolism Glucocorticoid Receptor Endogenous Metabolite corticosteroid Inhibitor inhibit glucocorticoid Predonine Hydroretrocortine anti-inflammatory orally active Metacortandralone inhibitor