Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 31,500 | |||
10 mg | 在庫あり | ¥ 45,000 | |||
25 mg | 在庫あり | ¥ 77,000 | |||
50 mg | 在庫あり | ¥ 114,000 | |||
100 mg | 在庫あり | ¥ 166,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 34,500 |
説明 | Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions. |
ターゲット&IC50 | Leishmania donovani:0.711 μM, T. brucei rhodesiense:0.144 μM |
In vitro | Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani. |
植物由来 |
分子量 | 208.25 |
分子式 | C12H16O3 |
CAS No. | 15121-94-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (288.12 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Primin 15121-94-5 Microbiology/Virology Antifection Primula inhibit obconica Inhibitor Bacterial inhibitor