Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may be used in HIV infection research.
説明 | R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may be used in HIV infection research. |
ターゲット&IC50 | LIMK1 (human):38 nM |
In vitro | R10015 as a lead compound that blocks LIMK activity by binding to the ATP-binding pocket.?R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release.?In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that LIMK inhibitors could be developed as a new class of broad-spectrum antiviral drugs. |
分子量 | 410.86 |
分子式 | C20H19ClN6O2 |
CAS No. | 2097938-51-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (152.12 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
R-10015 2097938-51-5 Cell Cycle/Checkpoint Microbiology/Virology LIM Kinase Reverse Transcriptase inhibit Inhibitor LIMKs R 10015 LIM Kinase (LIMK) R10015 inhibitor