Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
説明 | RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1]. |
別名 | CAY10441 |
分子量 | 309.41 |
分子式 | C19H23N3O |
CAS No. | 221529-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mM
You can also refer to dose conversion for different animals. 詳細
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RO1138452 221529-58-4 GPCR/G Protein Immunology/Inflammation Others Prostaglandin Receptor RO-1138452 CAY 10441 CAY-10441 CAY10441 Inhibitor inhibit RO 1138452 inhibitor