Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 55,000 | |||
10 mg | 在庫あり | ¥ 83,500 | |||
25 mg | 在庫あり | ¥ 141,000 | |||
50 mg | 在庫あり | ¥ 200,500 | |||
100 mg | 在庫あり | ¥ 271,000 | |||
500 mg | 在庫あり | ¥ 546,500 |
ターゲット&IC50 | Syk:5.6 nM |
In vitro | RO9021 effectively inhibits the anti-IgM induced phosphorylation of key signaling proteins including BTK, PLCγ2, AKT, and ERK, thereby demonstrating its capacity to block SYK kinase activity and consequently attenuate the B-cell receptor (BCR) downstream signaling cascade. This compound selectively targets B-cell receptor signaling, underscored by its role as a highly selective inhibitor of SYK. Its selectivity is evidenced by low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that among 392 kinases tested, SYK is the sole kinase significantly competed by RO9021 with 99% effectiveness. Moreover, RO9021 exhibits comparable inhibitory potency (IC50=22.8±1.7 nM) in assays measuring FcεR-mediated mast cell activation and degranulation, highlighting its broad potential in modulating immune responses [1]. |
分子量 | 355.44 |
分子式 | C18H25N7O |
CAS No. | 1446790-62-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3 mg/mL (8.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RO9021 1446790-62-0 Angiogenesis Tyrosine Kinase/Adaptors Syk Spleen tyrosine kinase Inhibitor RO 9021 inhibit RO-9021 inhibitor