Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 12,500 | |||
50 mg | 在庫あり | ¥ 19,500 | |||
100 mg | 在庫あり | ¥ 30,000 | |||
200 mg | 在庫あり | ¥ 49,000 | |||
500 mg | 在庫あり | ¥ 82,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
ターゲット&IC50 | D2 receptor:3.57 nM(Ki), α2C-adrenoceptor:1.3 nM(Ki), D2L receptor:4.16 nM(Ki), D3 receptor:3.6 nM(Ki), 5-HT2A:0.17 nM(Ki) |
In vitro | In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain. |
In vivo | In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM. |
別名 | Risperidal, R 64 766 |
分子量 | 410.48 |
分子式 | C23H27FN4O2 |
CAS No. | 106266-06-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.1 mg/mL (10 mM)
Ethanol: 4.1 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Risperidone 106266-06-2 GPCR/G Protein Membrane transporter/Ion channel Neuroscience P-gp Adrenergic Receptor 5-HT Receptor Dopamine Receptor inhibit Cluster of differentiation 243 Multidrug resistance protein 1 5-hydroxytryptamine Receptor CD243 Risperidal MDR1 R 64 766 Inhibitor P-glycoprotein Serotonin Receptor Pgp ABCB1 inhibitor