Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 21,000 | |||
25 mg | 在庫あり | ¥ 43,500 | |||
50 mg | 在庫あり | ¥ 64,500 | |||
100 mg | 在庫あり | ¥ 97,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors. |
ターゲット&IC50 | 5-HT:70 nM(Kd), NET:5.4 nM(Kd) |
別名 | Gamanil, Amplit, Leo 640, Lopramine |
分子量 | 418.96 |
分子式 | C26H27ClN2O |
CAS No. | 23047-25-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (114.57 mM)
You can also refer to dose conversion for different animals. 詳細
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Lofepramine 23047-25-8 GPCR/G Protein Neuroscience 5-HT Receptor Norepinephrine Inhibitor inhibit Gamanil Amplit Leo 640 Lopramine inhibitor