Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 95,000 | |||
10 mg | 在庫あり | ¥ 135,500 | |||
25 mg | 在庫あり | ¥ 216,500 | |||
50 mg | 在庫あり | ¥ 291,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 85,000 |
説明 | Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65. |
In vitro | To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes. |
植物由来 |
別名 | Rubiadin 1-methyl ether |
分子量 | 268.26 |
分子式 | C16H12O4 |
CAS No. | 7460-43-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.68 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rubiadin-1-methyl ether 7460-43-7 Microbiology/Virology NF-Κb NF-κB Anti-infection Inhibitor Nuclear factor-kappaB Nuclear factor-κB Rubiadin 1-methyl ether Rubiadin1methyl ether Rubiadin 1 methyl ether inhibit inhibitor