keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,500 | |||
10 mg | 在庫あり | ¥ 12,000 | |||
25 mg | 在庫あり | ¥ 22,000 | |||
50 mg | 在庫あり | ¥ 31,000 | |||
100 mg | 在庫あり | ¥ 45,000 | |||
500 mg | 在庫あり | ¥ 112,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM. |
ターゲット&IC50 | COX-2:0.28 μM. |
In vitro | Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. [1] |
細胞研究 | Rutaecarpine is dissolved in DMSO and diluted with appropriate medium before use. COX-1 and COX-2 cDNA-transfected HEK293 cells are prepared. For measuring inhibitory activity on COX-1 and COX-2 by rutaecarpine, cells in 1 mL of culture medium are seeded into each well of 24-well. After culture for 4 days, the supernatants are removed and 250 mL of fresh medium is added to the cells with or without rutaecarpine. After preincubation for 5 h at 37°C, the cells are further incubated at 37°C for 30 min with 50 mM arachidonic acid. All reactions are stopped by centrifugation at 120 g at 4°C for 5 min. Concentrations of PGE2 in the supernatant are measured[1]. |
植物由来 |
別名 | Rutacarpine, Rhetine, Rutecarpine |
分子量 | 287.32 |
分子式 | C18H13N3O |
CAS No. | 84-26-4 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 18.33 mg/mL (63.81 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Rutaecarpine 84-26-4 Immunology/Inflammation Neuroscience COX Rutacarpine Inhibitor inhibit Rhetine Cyclooxygenase Rutecarpine inhibitor