Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 35,500 | |||
25 mg | 在庫あり | ¥ 72,000 | |||
50 mg | 在庫あり | ¥ 113,500 | |||
100 mg | 在庫あり | ¥ 166,000 |
説明 | SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor. |
In vitro | 57461A is a potent competitive inhibitor of recombinant human LTA(4) hydrolase when either LTA(4) (IC(50) = 2.5 nM, K(i) = 23 nM) or peptide substrates (IC(50) = 27 nM) are used.?In human whole blood, the IC(50) for calcium ionophore-induced LTB(4) production was 49 nM, indicative of good cell penetration.?Whole blood production of the cyclooxygenase metabolite thromboxane B(2) was not affected.?SC-57461A was also active in several other species, including mouse, rat, dog, and rhesus monkey.?The data indicate that SC-57461A is a potent and selective inhibitor of LTA(4) hydrolase[2]. |
分子量 | 363.9 |
分子式 | C20H26ClNO3 |
CAS No. | 423169-68-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.4 mg/mL
You can also refer to dose conversion for different animals. 詳細
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SC-57461A 423169-68-0 Metabolism Aminopeptidase inhibit SC57461A SC 57461A Leukotriene A4 Inhibitor orally active LTA4 hydrolase inhibitor