Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
説明 | SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) |
ターゲット&IC50 | mGlu5 (human):0.4 μM |
In vivo | SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1]. |
別名 | 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 |
分子量 | 213.24 |
分子式 | C12H11N3O |
CAS No. | 31993-01-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17 mg/ml(79.72 mM)
You can also refer to dose conversion for different animals. 詳細
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SIB-1757 31993-01-8 Neuroscience GluR mGluR 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 SIB 1757 Metabotropic glutamate receptors SIB1757 inhibit Inhibitor 6-methyl-2-[phenyldiazenyl]pyridin-3 inhibitor