Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.
説明 | SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases. |
In vitro | SKA-111 (1 μM; 5 min) causes KCa3.1 membrane hyperpolarization in porcine endothelial cells. SKA-111 induces significantly enhanced Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in porcine large coronary arteries (PCA).[1] |
In vivo | SKA-111 (1 μM; Cardiac perfusion; Langendorff in rat hearts; ) improves Bradykinin-induced coronary artery dilation in isolated rat hearts. SKA-111 potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.[1] |
別名 | SKA 111, SKA111 |
分子量 | 214.29 |
分子式 | C12H10N2S |
CAS No. | 1369170-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.86 mg/mL (200 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SKA-111 1369170-24-0 Membrane transporter/Ion channel Potassium Channel SKA 111 SKA111 Inhibitor inhibitor inhibit