Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY 303511 hydrochloride is a potent mTOR inhibitor
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 17,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 113,500 | |||
100 mg | 在庫あり | ¥ 165,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 19,500 |
説明 | LY 303511 hydrochloride is a potent mTOR inhibitor |
ターゲット&IC50 | mTOR: |
In vitro | LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. |
別名 | LY303511 hydrochloride |
分子量 | 342.82 |
分子式 | C19H19ClN2O2 |
CAS No. | 2070014-90-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (145.85 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LY 303511 hydrochloride 2070014-90-1 Apoptosis Membrane transporter/Ion channel PI3K/Akt/mTOR signaling mTOR Potassium Channel TNF TNFR LY-303511 LY 303511 Hydrochloride TNF Receptor inhibit LY 303511 Tumor Necrosis Factor Receptor LY-303511 Hydrochloride Inhibitor LY303511 hydrochloride LY303511 Hydrochloride LY303511 KcsA inhibitor