Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 57,000 | |||
25 mg | 在庫あり | ¥ 102,500 | |||
50 mg | 在庫あり | ¥ 151,500 | |||
100 mg | 在庫あり | ¥ 215,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 42,000 |
説明 | SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively) |
ターゲット&IC50 | Ca2+ channel, L-type:33 nM (EC50, in polarized conditions), Ca2+ channel, L-type:4.1 nM (EC50, in depolarized conditions) |
In vitro | Acute treatment with SR33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes.?Indeed, a SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation.?Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR33805.?Finally, administration of a single intra-peritoneal bolus of SR33805 (20 mg/kg) improved end-systolic strain and fractional shortening of MI hearts[1] |
分子量 | 564.74 |
分子式 | C32H40N2O5S |
CAS No. | 121345-64-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (48.69 mM)
You can also refer to dose conversion for different animals. 詳細
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SR33805 121345-64-0 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels channel failing Ca2+ channels Ca2+ SR 33805 SR-33805 acute L-type Inhibitor inhibit depolarized polarized hearts chronic inhibitor