Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). |
ターゲット&IC50 | 5-HT6 receptor:13 nM (ki), 5-HT7 receptor (human):168 nM (ki), 5-HT2B receptor:245 nM (ki) |
In vitro | ST1936 appears to be relatively selective for the 5-HT6 receptors, although it has shown affinity also for 5-HT2B, 5-HT1A, 5-HT7 receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters. |
In vivo | Extracellular single-unit recordings are performed from putative dopamine-containing neurons in the SNc and VTA of anesthetised rats (Male Sprague-Dawley rats).In the VTA, ST1936 induces either dose-related increases (45% of cells) or decreases in basal activity of these dopaminergic neurons. |
分子量 | 326.78 |
分子式 | C15H19ClN2O4 |
CAS No. | 1782228-83-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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ST1936 oxalate 1782228-83-4 GPCR/G Protein Neuroscience 5-HT Receptor phosphorylation Beta Receptor 5-HT6 receptor subtype Adrenergic Receptor ST-1936 ST1936 prefrontal cortex ST-1936 Oxalate Inhibitor ST 1936 5-hydroxytryptamine Receptor ST-1936 oxalate ST 1936 Oxalate ST1936 Oxalate Fyn Serotonin Receptor inhibit neurons inhibitor