Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 8,500 | |||
5 mg | 在庫あり | ¥ 13,500 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 87,000 | |||
100 mg | 在庫あり | ¥ 130,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 15,500 |
説明 | SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells. |
キナーゼ試験 | The potency of JNJ-42041935 for inhibition of the structurally related enzyme FIH is assessed by methods similar to those described for PHD2. In brief, activity of FIH is determined using purified glutathione transferase-tagged full-length FIH amino acids 1 to 350 and a synthetic HIF-1α peptide corresponding to residues Asp788 to Leu822. Compounds are preincubated with 17.1 nM FIH for 30 min, followed by a 10-min incubation with 1 μM [2-14C]2-oxoglutarate, in the presence of 10 μM FeNH4SO4 in reaction buffer. The selectivity of JNJ-42041935 for inhibition of a range of other targets available for testing in commercial assays is also assessed at concentrations of 1 and 10 μM[1]. |
分子量 | 421.52 |
分子式 | C22H23N5O2S |
CAS No. | 522650-83-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.14 mg/mL (16.95 mM)
You can also refer to dose conversion for different animals. 詳細
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SW044248 522650-83-5 DNA Damage/DNA Repair Topoisomerase inhibit SW-044248 SW 044248 Inhibitor inhibitor