Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 7,500 |
2 mg | 在庫あり | ¥ 9,500 |
5 mg | 在庫あり | ¥ 15,500 |
10 mg | 在庫あり | ¥ 22,500 |
25 mg | 在庫あり | ¥ 43,000 |
50 mg | お問い合わせ | ¥ 77,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,000 |
説明 | Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α). |
ターゲット&IC50 | CK2α:1 nM, CK2α':1 nM |
In vitro | Silmitasertib induces cytotoxicity and apoptosis, and exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways[3]. Silmitasertib (CX-4945) resultes in cell-cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells, attenuates PI3K/Akt signalingand. The antiproliferative activity of Silmitasertib is correlated with expression levels of the CK2α catalytic subunit, attenuation of PI3K/Akt signaling[1]. Silmitasertib with PS-341 treatment prevents leukemic cells from engaging a functional UPR in order to buffer the PS-341-mediated proteotoxic stress in ER lumen, and decreases pro-survival ER chaperon BIP/Grp78 expression[2]. |
In vivo | Silmitasertib (CX-4945), administered at doses of 25 or 75 mg/kg orally, was well tolerated and demonstrated strong antitumor effects alongside significant decreases in the mechanistic biomarker phospho-p21 (T145) in murine xenograft models[1]. |
別名 | CX-4945 sodium salt |
分子量 | 371.75 |
分子式 | C19H11ClN3NaO2 |
CAS No. | 1309357-15-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 16.67 mg/mL (44.84 mM), Sonication is recommended.
DMSO: 6 mg/mL (16.13 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Silmitasertib sodium salt 1309357-15-0 Autophagy Metabolism Stem Cells Casein Kinase Silmitasertib CX4945 inhibit CX-4945 sodium salt Inhibitor CX-4945 sodium CX 4945 CX-4945 Silmitasertib sodium inhibitor