Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 30,500 | |||
5 mg | 在庫あり | ¥ 59,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 | |||
100 mg | 在庫あり | ¥ 294,000 |
説明 | Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor. |
In vitro | Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1]. |
In vivo | Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2]. |
分子量 | 877 |
分子式 | C45H64N8O10 |
CAS No. | 137201-62-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (57.01 mM)
You can also refer to dose conversion for different animals. 詳細
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Spinorphin 137201-62-8 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibit Inhibitor inhibitor