Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
説明 | TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM. |
ターゲット&IC50 | MCH1R (mouse):3.0 nM , MCH1R (human):(ki)3.4 nM , MCH1R (human):5.6 nM , MCH1R (human):5.6 nM, MCH1R (human):3.4 nM (ki), MCH1R (mouse):3.0 nM |
In vitro | In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2]. |
In vivo | In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2]. |
分子量 | 408.47 |
分子式 | C24H25FN2O3 |
CAS No. | 864756-35-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 36.8 mg/mL (90.0 mM)
DMSO: 18.0 mg/mL (44.1 mM)
You can also refer to dose conversion for different animals. 詳細
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TC-MCH 7c 864756-35-4 GPCR/G Protein Melanin-concentrating Hormone Receptor (MCHR) TCMCH 7c TC MCH 7c Inhibitor inhibitor inhibit