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T39727 |
ERα degrader-2
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ERK
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ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prev... |
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T13722 |
Homo-PROTAC pVHL30 degrader 1
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Others
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Ligand for E3 Ligase
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Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC. |
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T9236 |
WSB1 Degrader 1
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Others
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E1/E2/E3 Enzyme
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WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects. |
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T13721 |
Homo-PROTAC cereblon degrader 1
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Others
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Ligand for E3 Ligase
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Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. |
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T69753 |
HDAC6 degrader 9c
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HDAC
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HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases. |
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T8745 |
PROTAC BRAF-V600E degrader-1
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Compound 23 |
Raf
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PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF. |
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T4207 |
(S,R,S)-AHPC hydrochloride
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VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride |
Others
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Ligand for E3 Ligase
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(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
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T39902 |
PROTAC IRAK4 degrader-5
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PROTAC IRAK4 degrader-5 |
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PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader. |
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T39920 |
PROTAC IRAK4 degrader-3
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PROTAC IRAK4 degrader-3 |
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PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. |
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T36242 |
PROTAC BRD4 Degrader-5
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PROTAC BRD4 Degrader-5 |
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PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. |
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T39903 |
PROTAC IRAK4 degrader-6
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PROTAC IRAK4 degrader-6 |
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PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). |
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T40074 |
PROTAC BRD4 Degrader-15
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PROTAC BRD4 Degrader-15 |
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PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BR... |
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T36628 |
PROTAC BRD4 Degrader-8
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PROTAC BRD4 Degrader-8 |
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PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells... |
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T40072 |
PROTAC BRD4 Degrader-9
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PROTAC BRD4 Degrader-9 |
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PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate... |
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T40073 |
PROTAC BRD4 Degrader-10
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PROTAC BRD4 Degrader-10 |
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PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca... |
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T37329 |
PROTAC IDO1 Degrader-1
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PROTAC IDO1 Degrader-1 |
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PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the... |
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T39901 |
PROTAC IRAK4 degrader-4
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PROTAC IRAK4 degrader-4 |
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PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). |
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T40250 |
SHP2 protein degrader-1
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SHP2 protein degrader-1 |
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SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying dis... |
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T39996 |
PROTAC CDK9 degrader-4
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PROTAC CDK9 degrader-4 |
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PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9... |
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T40075 |
PROTAC BRD4 Degrader-13
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PROTAC BRD4 Degrader-13 |
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PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel... |
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T74982 |
Akt3 degrader 1
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Akt3 Degrader 1 (compound 12l), a selective Akt3 degrader, effectively overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Besides its role in overcoming drug resistance, it exhibits anti-proliferative prope... |
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T40143 |
PROTAC CBP/P300 Degrader-1
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PROTAC CBP/P300 Degrader-1 |
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PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines. |
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T36256 |
LC-2
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LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 |
PROTACs
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LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recru... |
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T40112 |
PROTAC PD-1/PD-L1 degrader-1
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PROTAC PD-1/PD-L1 degrader-1 |
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PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppr... |
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T39685 |
PCSK9 degrader 1
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PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function. |
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T39374 |
PROTAC BET Degrader-10
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PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that co... |
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T39837 |
PROTAC ERRα Degrader-3
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PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capabilit... |
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T5439 |
BRD4 degrader AT1
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Epigenetic Reader Domain
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BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. |
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T36243 |
PROTAC RIPK degrader-6
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PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1]. |
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T13845 |
PROTAC PARP1 degrader
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Others
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PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM). |
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T5438 |
PROTAC CDK9 Degrader-1
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CDK
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PROTAC CDK9 Degrader-1 is a selective CDK9 degrader. |
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T18609 |
PROTAC ERRα Degrader-2
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Others
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PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related r... |
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T12560 |
PROTAC BRD9 Degrader-1
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Epigenetic Reader Domain
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PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM. |
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T16667 |
PROTAC Sirt2 Degrader-1
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Sirtuin
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Si... |
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T18632 |
PROTAC MDM2 Degrader-2
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Others
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PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, thi... |
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T10485 |
PROTAC Bcl2 degrader-1
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BCL
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PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM). |
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T18636 |
PROTAC ERα Degrader-1
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Others
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PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα). |
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T18605 |
PROTAC ERα Degrader-2
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Others
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PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cel... |
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T13835 |
PROTAC BRD4 Degrader-3
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|
Epigenetic Reader Domain
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PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4. |
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T13834 |
PROTAC BRD4 Degrader-2
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM). |
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T17728 |
PROTAC CDK9 degrader-2
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Others
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PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to... |
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T18634 |
PROTAC MDM2 Degrader-4
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Others
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PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. |
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T18631 |
PROTAC MDM2 Degrader-1
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Others
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PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. |
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T12556 |
PROTAC B-Raf degrader 1
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Raf
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PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity. |
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T13840 |
PROTAC FAK degrader 1
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Others
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PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM). |
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T13847 |
PROTAC SGK3 degrader-1
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SGK3-PROTAC1 |
SGK
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PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of can... |
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T13842 |
PROTAC IRAK4 degrader-1
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Others
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PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4). |
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T13833 |
PROTAC BRD4 Degrader-1
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM). |
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T11975 |
PROTAC Mcl1 degrader-1
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BCL
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PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ... |
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T18633 |
PROTAC MDM2 Degrader-3
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Others
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PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. |
