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T8824 |
CRBN modulator-1
|
WUN29654 |
Others
,
Ligand for E3 Ligase
|
|
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM. |
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T9360 |
CRBN ligand-9
|
2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione |
Ligand for E3 Ligase
|
|
CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN. |
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T35479 |
CRBN-6-5-5-VHL
|
|
|
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Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.
... |
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T18604 |
PROTAC CRBN Degrader-1
|
|
Others
|
|
PROTAC CRBN Degrader-1 is a chemical compound consisting of a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. It functions as a cereblon (CRBN) degrader[1]. |
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T18787 |
TD-165
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|
Others
,
Ligand for E3 Ligase
|
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TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1]. |
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T16363 |
NVP-2
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|
Apoptosis
,
CDK
|
|
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD... |
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T9370 |
DCBP-1
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|
Epigenetic Reader Domain
,
Ligand for E3 Ligase
|
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dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. |
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T10765 |
Eragidomide
|
CC-90009,Cereblon modulator 1 |
Apoptosis
,
Ligand for E3 Ligase
,
Molecular Glues
|
|
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. |
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T9291 |
Thalidomide-5-OH
|
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione |
Others
,
Ligand for E3 Ligase
|
|
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a link... |
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T7791 |
Iberdomide
|
CC-220 |
Apoptosis
,
Ligand for E3 Ligase
|
|
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). |
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T40016 |
Thalidomide-NH-CH2-COOH
|
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase
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|
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. |
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T40503 |
Thalidomide-5-methyl
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|
Ligand for E3 Ligase
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Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein. |
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T14893 |
CC-885
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|
Others
,
Ligand for E3 Ligase
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CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity. |
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T39910 |
Desmorpholinyl Navitoclax-NH-Me
|
Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me |
BCL
|
|
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. |
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T40013 |
Thalidomide-O-CH2CONH-CH2COOH
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|
Others
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Thalidomide-O-CH2CONH-CH2COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40012 |
Thalidomide-CH2CONH-C2-COOH
|
|
Others
|
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Thalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology. |
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T22922 |
Lenalidomide hemihydrate
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|
TNF
,
Ligand for E3 Ligase
,
Molecular Glues
|
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Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. |
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T13721 |
Homo-PROTAC cereblon degrader 1
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Others
,
Ligand for E3 Ligase
|
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Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. |
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T18066 |
Lenalidomide-OH
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|
Ligand for E3 Ligase
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Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei... |
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T40001 |
Pomalidomide-C6-COOH
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|
Others
|
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Pomalidomide-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40005 |
Pomalidomide-C2-COOH
|
|
Others
|
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Pomalidomide-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40014 |
Pomalidomide-C4-OH
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Others
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Pomalidomide-C4-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40007 |
Pomalidomide-C5-COOH
|
|
Others
|
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Pomalidomide-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40000 |
Pomalidomide-C3-I
|
|
Others
|
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Pomalidomide-C3-I is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40006 |
Pomalidomide-CH2CONH-C2-COOH
|
|
Others
|
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Pomalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40015 |
Pomalidomide-PEG2-NH2 hydrochloride
|
|
Others
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Pomalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40008 |
Pomalidomide-C6-I TFA
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Others
|
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Pomalidomide-C6-I TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40011 |
Thalidomide-CH2CONH-C3-COOH
|
|
Others
|
|
Thalidomide-CH2CONH-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40009 |
Pomalidomide-C4-COOH
|
|
Others
|
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Pomalidomide-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40010 |
Pomalidomide-C9-COOH
|
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Others
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Pomalidomide-C9-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40002 |
Pomalidomide-C3-NH2 hydrochloride
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Others
,
E3 Ligase Ligand-Linker Conjugate
|
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Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T40004 |
Pomalidomide-C7-NH2 hydrochloride
|
|
Others
|
|
Pomalidomide-C7-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T7763 |
Thalidomide-4-OH
|
Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase
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|
Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs |
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T7753 |
Thalidomide-O-COOH
|
Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others
,
Ligand for E3 Ligase
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|
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. |
|
T7755 |
Thalidomide 4-fluoride
|
E3 ligase Ligand 4 |
IRAK
,
Ligand for E3 Ligase
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|
Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) ... |
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T40003 |
Thalidomide-NH-C6-NH2 hydrochloride
|
|
Others
,
E3 Ligase Ligand-Linker Conjugate
|
|
Pomalidomide-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
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T18064 |
Lenalidomide-Br
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|
Ligand for E3 Ligase
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Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a... |
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T1642 |
Lenalidomide
|
CC-5013 |
Apoptosis
,
TNF
,
Ligand for E3 Ligase
,
Molecular Glues
|
|
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines. |
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T17069 |
THAL-SNS-032
|
|
CDK
|
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THAL-SNS-032 is a selective CDK9 degrader PROTAC. |
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T18831 |
Thalidomide-propargyl
|
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Others
,
Ligand for E3 Ligase
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|
Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs. |
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T14908 |
CCT367766
|
|
PROTACs
|
|
CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN... |
|
T34888 |
TL12-186
|
TL12 186,TL12186 |
CDK
,
Ligand for E3 Ligase
|
|
TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively. |
|
T77915 |
CCT367766 formic
|
|
PROTACs
|
|
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at... |
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T40099 |
ALV2
|
|
|
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ALV2 is a potent and selective Helios degrader compound that binds to the CRBN protein, exhibiting an IC50 value of 0.57 μM. Helios, a zinc-finger transcription factor, plays a crucial role in preserving a stable T reg c... |
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T40333 |
ZXH-4-137
|
|
|
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ZXH-4-137 is a potent and selective CRBN degrader ( PROTAC ). |
|
T38457 |
Lenalidomide-4-OH
|
|
|
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Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC. |
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T40547 |
Lenalidomide-4-aminomethyl hydrochloride
|
|
|
|
Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the lig... |
|
T39679 |
Lenalidomide-I
|
|
|
|
Lenalidomide-I (Compound 72) is a derivative of the cereblon (CRBN) ligand, Lenalidomide, with affinity for E3 ubiquitin ligase. It facilitates the recruitment of CRBN protein. Lenalidomide-I can be utilized in PROTACs, ... |
|
T77971 |
Pomalidomide-C11-NH2 hydrochloride
|
|
|
|
Pomalidomide-C11-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide used to recruit the CRBN protein. This compound can be conjugated with a linker to the protein ligand to assemble a PROTAC [1]. |
|
T77980 |
Pomalidomide-5-C10-NH2 hydrochloride
|
|
|
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Pomalidomide-5-C10-NH2 hydrochloride, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand via a linker to construct a PROTAC [1]. |
