Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 85,500 | |||
100 mg | 在庫あり | ¥ 143,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 19,500 |
説明 | VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes. |
ターゲット&IC50 | VHL/HIFα:80 to 90 nM (Kd) |
In vitro | VH298, a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.?We show that VH298 engages with high affinity and specificity with VHL as its only major cellular target, leading to selective on-target accumulation of hydroxylated HIF-α in a concentration- and time-dependent fashion in different cell lines, with subsequent upregulation of HIF-target genes at both mRNA and protein levels.?VH298 represents a high-quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. |
分子量 | 523.65 |
分子式 | C27H33N5O4S |
CAS No. | 2097381-85-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 78.3mg/ml (149.53 Mm)
You can also refer to dose conversion for different animals. 詳細
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VH-298 2097381-85-4 Angiogenesis Chromatin/Epigenetic Others PROTAC Ligand for E3 Ligase HIF E3 ligase-recruiting Moiety Inhibitor VH 298 Ligands for E3 Ligase inhibit VH298 inhibitor