Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 10,500 | |||
10 mg | 在庫あり | ¥ 14,500 | |||
25 mg | 在庫あり | ¥ 20,500 | |||
50 mg | 在庫あり | ¥ 29,000 | |||
100 mg | 在庫あり | ¥ 39,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir. |
In vitro | GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |
別名 | GS-7340 |
分子量 | 476.47 |
分子式 | C21H29N6O5P |
CAS No. | 379270-37-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (115.43 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 88 mg/mL (184.7 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tenofovir alafenamide 379270-37-8 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase Human immunodeficiency virus GS7340 Inhibitor inhibit HIV GS-7340 GS 7340 inhibitor