Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,500 | |||
50 mg | 在庫あり | ¥ 13,500 | |||
100 mg | お問い合わせ | ¥ 21,000 | |||
500 mg | お問い合わせ | ¥ 34,000 |
説明 | Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis. |
In vitro | Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells.?By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS.Of note, DHODH blockade does not affect resting or homeostatically proliferating hematopoietic cell lines, as pyrimidine pools in these cells can be generated through an alternate 'salvage pathway,” which is independent of the DHODH.As a result.Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes[1]. |
別名 | A 77-1726 |
分子量 | 270.21 |
分子式 | C12H9F3N2O2 |
CAS No. | 163451-81-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26 mg/mL (96.22 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Teriflunomide 163451-81-8 Others A77 1726 Inhibitor inhibit A 77-1726 inhibitor