Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 86,500 | |||
25 mg | 在庫あり | ¥ 146,500 | |||
50 mg | 在庫あり | ¥ 204,000 | |||
100 mg | 在庫あり | ¥ 282,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,500 |
説明 | UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
In vitro | UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs. |
In vivo | In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284. |
分子量 | 441.56 |
分子式 | C26H35NO5 |
CAS No. | 299420-83-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (55.62 mM), Sonication is recommended.
H2O: 50 mg/mL (113.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UC-514321 299420-83-0 Apoptosis JAK/STAT signaling Stem Cells STAT AML myeloid UC 514321 low toxicity acute leukemia inhibit UC514321 Inhibitor inhibitor