Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 62,500 | |||
50 mg | 在庫あり | ¥ 100,500 | |||
100 mg | 在庫あり | ¥ 149,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,500 |
説明 | VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters. |
ターゲット&IC50 | KCC2:61 nM |
別名 | N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
分子量 | 382.5 |
分子式 | C19H18N4OS2 |
CAS No. | 1391737-01-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (52.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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VU0463271 1391737-01-1 Membrane transporter/Ion channel Potassium Channel Inhibitor KcsA VU-0463271 VU 0463271 inhibit N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide inhibitor