Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation
説明 | Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation |
In vivo | vacuolin-1 potently and reversibly inhibited the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes[1]. |
分子量 | 577.42 |
分子式 | C26H24IN7O |
CAS No. | 351986-85-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.77 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Vacuolin-1 351986-85-1 Autophagy PI3K/Akt/mTOR signaling PI3K Inhibitor Fab1 Vacuolin1 Vacuolin 1 PIKfyve membrane repair inhibit exocytosis HeLa cells inhibitor