Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,500 | |||
2 mg | 在庫あり | ¥ 25,000 | |||
5 mg | 在庫あり | ¥ 35,500 | |||
10 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 69,000 |
説明 | AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. |
ターゲット&IC50 | PI3Kγ:1 nM (ki), PI3Kα:4 nM (ki), PI3Kβ:6 nM (ki), PI3Kδ:2 nM (ki) |
In vitro | AMG 511 shows the inhibition of AKT (Ser473) phosphorylation in U87 malignant glioma (MG) cells with an IC50 of 4 nM[1]. |
In vivo | AMG 511 shows excellent in vivo efficacy and pharmacokinetic profile[1]. AMG 511 potently blocks the targeted PI3K pathway in a mouse liver pharmacodynamic model (3-30 mg/kg; p.o.). And it inhibits tumor growth in a U87 MG glioblastoma xenograft model (3-30 mg/kg; p.o.; daily; for 12 days)[1]. |
分子量 | 517.58 |
分子式 | C22H28FN9O3S |
CAS No. | 1253573-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (64.40 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AMG 511 1253573-53-3 PI3K/Akt/mTOR signaling PI3K AMG-511 Inhibitor AMG511 PI3Kβ malignant PI3Kγ PI3Kα Phosphoinositide 3-kinase inhibit glioblastoma PI3Kδ glioma inhibitor