Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 44,000 | |||
5 mg | 在庫あり | ¥ 110,500 | |||
10 mg | 在庫あり | ¥ 158,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 340,000 |
説明 | Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer. |
In vitro | Vorozole inhibits aromatase activity in FSH-stimulated rat granulosa cells with an IC 50 s of 1.4 nM.[3] |
In vivo |
Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 days; Female Sprague-Dawley rats), while displaying an antitumor effect, also elevates serum levels of insulin-like growth factor (IGF)-1 and testosterone.[3] Vorozole (0.8-1.25 mg/kg; p.o.; 5 days; Female Sprague-Dawley rats), in a dose-dependent manner, decreased uterine weight and effectively suppressed tumor aromatase in ovariectomized nude mice.[3] |
別名 | R83839, R 83839, R-83839, (+)-Vorozole, R83842 |
分子量 | 324.77 |
分子式 | C16H13ClN6 |
CAS No. | 129731-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (153.96 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Vorozole 129731-10-8 Endocrinology/Hormones Metabolism Aromatase P450 R-83842 R 83842 R83839 R 83839 R-83839 (+)-Vorozole R83842 Inhibitor inhibitor inhibit