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T60022 |
Aromatase-IN-2
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Others
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Aromatase-IN-2 has anti-inflammatory, antitumor and antiasthmatic effects. |
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T60006 |
Aromatase inhibitor 23
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Others
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Aromatase inhibitor 23 is an inhibitor that target protein-protein interactions in RAD51 family of recombinases. |
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T61444 |
Nonsteroidal aromatase inhibitor 1
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|
|
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Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for researc... |
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T61463 |
Monoamine oxidase/Aromatase-IN-1
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|
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Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potentia... |
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T7197 |
Fadrozole
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Aromatase
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Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM) |
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T11991 |
Mefentrifluconazole
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|
P450
,
Antifungal
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Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ... |
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T0393 |
Anastrozole
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ZD1033 |
Aromatase
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Anastrozole (ZD1033)(ZD1033), a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM), has no obvious effect on adrenocorticoid hormone synthesis. |
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T7556 |
Fadrozole hydrochloride
|
CGS 16949A |
Aromatase
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Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish. |
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T1103 |
Aminoglutethimide
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DL-Aminoglutethimide,BA-16038,NSC-330915 |
Aromatase
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Aminoglutethimide (BA-16038), an aromatase inhibitor, is used in the therapy of advanced BREAST Y. |
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T20625 |
Prochloraz
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Sporgon,Prelude |
Estrogen Receptor/ERR
,
AhR
,
Androgen Receptor
,
Antifungal
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Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... |
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T4281 |
Endoxifen
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(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen |
Estrogen Receptor/ERR
,
Aromatase
,
Estrogen/progestogen Receptor
,
Parasite
,
Drug Metabolite
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(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f... |
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T71708 |
Minamestane
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Aromatase
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Minamestane is a novel irreversible aromatase inhibitor.Minamestane induces time-dependent inhibition of human placental aromatase with a half-life of 4 minutes and a K of 59 nM.Minamestane has antitumor activity. |
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T27320 |
Finrozole
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MPV 2213ad,MPV-2213ad,MPV 2213,MPV-2213,MPV2213ad |
Aromatase
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Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development. |
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T23549 |
YM 511
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P450
,
Aromatase
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YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly ... |
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T72310 |
Antibacterial agent 132
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Antifungal
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Antibacterial agent 132 showed antimicrobial activity against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg/mL and 62.50 μg/mL, respectively. Antibacterial agent 132 inhibited aroma... |
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T27918 |
LY 43578
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LY-43578,LY43578 |
P450
,
Aromatase
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LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (IC50 of 0.3 and 5 μm, respectively) in rat liver microsomes.... |
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T2280 |
Endoxifen (Z-isomer)
|
Endoxifen Z-isomer |
Estrogen Receptor/ERR
,
EGFR
,
Potassium Channel
,
Estrogen/progestogen Receptor
,
HER
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Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. |
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T26322 |
Vorozole
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R83839,R 83839,R-83839,(+)-Vorozole,R83842 |
P450
,
Aromatase
|
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Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer. |
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T26322L |
(-)-Vorozole
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(-)-Vorozole(Isomer-129731-10-8) |
P450
,
Aromatase
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(-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potency and selectivity. (-)-Vorozole has demonstrated antitumor activity in in vivo experiments. (-)-Vorozole is used in the study of breast cancer... |
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T6827L |
Endoxifen hydrochloride
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|
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Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for br... |
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T11847L |
Liarozole
|
R75251 dihydrochloride |
P450
,
Retinoid Receptor
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Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... |
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T12319 |
Org30958
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Aromatase
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Org30958 is a potent inhibitor of aromatase in vivo. |
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T27369 |
FR 901537
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FR901537,FR-901537 |
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FR 901537 is a new aromatase inhibitor with antitumor effects. |
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T70558 |
Org 33201
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Org 33201 is a potent aromatase inhibitor. |
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T71410 |
Cgs 18320B
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Cgs 18320B is a non-steroidal aromatase inhibitor |
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T7197L |
Fadrozole HCl hydrate
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Fadrozole,CGS-16949A,Fadrozole hydrochloride hemihydrate,CGS16949A,CGS 16949A |
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Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer. |
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T27922 |
LY 56110
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LY56110,LY-56110 |
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LY 56110 is a novel nonsteroidal aromatase inhibitor. |
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T70404 |
MPV-2213AD
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MPV-2213AD is an aromatase inhibitor. |
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T20683 |
Letrozole related compound B
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Letrozole specified impurity A |
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Letrozole related compound B is an impurity of aromatase inhibitor. |
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T25716 |
Liarozole fumarate
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Liazal,R85246,R-85246,R 85246 |
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Liarozole fumarate is used as a retinoic acid metabolism blocking agent (RAMBA) and an aromatase inhibitor. |
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T81012 |
Testololactone
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Testololactone, an aromatase inhibitor, may be utilized in breast carcinoma research [1]. |
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T27868 |
LY 113174
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LY-113174,LY113174 |
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LY 113174, a novel nonsteroidal aromatase inhibitor, may prove useful in the treatment of estrogen-dependent diseases. |
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T71897 |
Vatalanib succinate
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Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor. |
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T30837 |
Cgp 47645
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Leflutrozole,Cgp-47645,Cgp47645 |
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CGP 47645 (Leflurozole) is an oral active non-steroidal aromatase inhibitor and antitumor agent with anti-tumor and endocrine effects. |
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T30834 |
Cgp 45688
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Cgp45688,Cgp-45688 |
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CGP 45688 is an oral active non-steroidal aromatase inhibitor with anti-tumor and endocrine effects on rat breast tumors. |
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T61787 |
SYN20028567
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SYN20028567, an aromatase (CYP19) inhibitor, exhibits an IC50 value of 9.4 nM. It has potential applications in breast cancer research [1]. |
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T38424 |
(R)-Fadrozole
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FAD286,(R)-CGS 16949A free base,(R)-Fadrozole |
|
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(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp... |
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T71073 |
Tan 931
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Tan 931 is a nonsteroidal aromatase inhibitor that was first isolated from the culture filtrate of a soil isolate fungus, No. 8974 |
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T6060L |
Anabasine HCl
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BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653 |
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Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana. |
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T71010 |
Norendoxifen
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Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor... |
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T80057 |
Cytochrome P450 reductase
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|
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Cytochrome P450 reductase, a NADPH-cytochrome reductase, facilitates an optimal conformation of aromatase for substrate binding [1]. |
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T61919 |
Anticancer agent 78
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Anticancer agent 78 has anti-aromatase activity (IC50=0.9 μM）。 Anticancer agent 78 is an effective anticancer agent, showing cytotoxicity. Anticancer agent 78 has research potential in breast cancer. |
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T11847 |
Liarozole dihydrochloride
|
R75251 dihydrochloride |
Others
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Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lya... |
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T25716L |
Liarozole HCl
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R75251,Liarozole hydrochloride,R 75251,R-75251 |
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Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an incr... |
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T35676 |
17β-hydroxy Exemestane
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17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (... |
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T83907 |
10-Chloroestra-1,4-diene-3,17-dione
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10-chloro-1,4-Estradiene |
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10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor α (ERα) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aroma... |
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T78590 |
Dibenzylfluorescein
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DBF |
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Dibenzylfluorescein (DBF), a fluorogenic probe (Fluorescent dye), serves as a substrate for various cytochrome P450 (CYP) isoforms, such as CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). It is commonly utilized ... |
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T37560 |
Nidulin
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Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-r... |
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T71578 |
Endoxifen mesylate
|
|
|
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Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot... |
