store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 66,500 |
5 mg | 在庫あり | ¥ 148,500 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 420,000 |
50 mg | 在庫あり | ¥ 716,000 |
100 mg | 在庫あり | ¥ 1,145,500 |
説明 | ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease. |
ターゲット&IC50 | TGase 2:45 nM |
In vitro |
ZED-1227, at concentrations ranging from 0.1 μM to 1 μM for 24 hours, does not impact metabolic activity and proliferation in Huh7 cells and CaCo2 cells. This lack of effect suggests that ZED-1227 does not exhibit cytotoxic activity[1]. In an in vitro setting, ZED-1227, when applied at concentrations between 0.002 and 0.2 mg/mL for 30 minutes, inhibits transglutaminase 2 (TG2) in the small intestinal mucosa[1]. |
In vivo | In mice, ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to levels comparable to normal control levels. Additionally, ZED-1227 administration subdues intestinal inflammation in these mice[1].Furthermore, when administered orally (5 mg/kg; i.g.), ZED-1227 is effective in inhibiting TG2 in the small intestinal mucosa[1]. |
別名 | ZED-101, TAK-227 |
分子量 | 528.6 |
分子式 | C26H36N6O6 |
CAS No. | 1542132-88-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (189.18 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ZED-1227 1542132-88-6 Others Proteases/Proteasome Glutaminase ZED1227 ZED-101 ZED 1227 TAK-227 Inhibitor inhibitor inhibit