keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by inhibiting glutamine metabolism and stimulating the innate and adaptive immune system.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 72,000 |
5 mg | 在庫あり | ¥ 216,500 |
10 mg | 在庫あり | ¥ 379,000 |
25 mg | 在庫あり | ¥ 564,500 |
50 mg | 在庫あり | ¥ 762,000 |
100 mg | 在庫あり | ¥ 1,028,500 |
説明 | Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by inhibiting glutamine metabolism and stimulating the innate and adaptive immune system. |
In vitro | Treatment with Sirpiglenastat (DRP-104) exhibits broad immune cell modulation effects, including an increase in T cells, NK cells, and macrophages. Sirpiglenastat also reduces the levels of pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1]. |
In vivo | In CT26 bearing mice, treatment with Sirpiglenastat (DRP-104) at a dose of 0.5 mg/kg through subcutaneous injection once a day for 5 days results in a 90% inhibition of tumor growth by day 12, with a median survival of 36 days[1].Additionally, Sirpiglenastat treatment (0.5 mg/kg; s.c) significantly inhibits tumor growth in the H22 model[1]. |
別名 | DRP-104 |
分子量 | 441.48 |
分子式 | C22H27N5O5 |
CAS No. | 2079939-05-0 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL(181.21 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Sirpiglenastat 2079939-05-0 Proteases/Proteasome Glutaminase DRP-104 Inhibitor inhibitor inhibit