Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
説明 | ZM223 is an inhibitor of NEDD8 activating enzyme (NAE). |
In vitro | ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1]. |
別名 | ZM-223 |
分子量 | 502.53 |
分子式 | C23H17F3N4O2S2 |
CAS No. | 2031177-48-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (159.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ZM223 2031177-48-5 Ubiquitination E1/E2/E3 Enzyme ZM 223 ZM-223 Inhibitor inhibitor inhibit