Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 105,000 | |||
25 mg | 在庫あり | ¥ 173,000 | |||
50 mg | 在庫あり | ¥ 243,500 | |||
100 mg | 在庫あり | ¥ 328,500 | |||
500 mg | 約6-8 週間 | ¥ 656,500 |
説明 | Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity. |
In vitro | Mezigdomide-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. Mezigdomide exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. Mezigdomide is effective in CC-4047, CC-5013, and CC-220-resistant cell lines[1]. |
In vivo | Mezigdomide (1 mg/kg) showed 75% reduction in tumor volume when tumor-bearing mice were dosed orally for 21 days. Both the 3 and 10 mg/kg doses gave near maximal response in this model[2]. |
別名 | CC-92480 |
分子量 | 567.61 |
分子式 | C32H30FN5O4 |
CAS No. | 2259648-80-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (8.81 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Mezigdomide 2259648-80-9 Apoptosis PROTAC Ubiquitination E1/E2/E3 Enzyme Molecular Glues Ubiquitin ligase Ubiquitin activating enzyme CC 92480 CC92480 inhibit E1 activating enzyme CC-92480 E2 conjugating enzyme Inhibitor Ubiquitin conjugating enzyme E3 ligating enzyme inhibitor