Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 25,000 | |||
5 mg | 在庫あり | ¥ 60,500 | |||
10 mg | 在庫あり | ¥ 97,000 | |||
25 mg | 在庫あり | ¥ 200,500 | |||
50 mg | 在庫あり | ¥ 268,500 | |||
100 mg | 在庫あり | ¥ 363,000 |
説明 | AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells. |
ターゲット&IC50 | AMPK α1:107 nM, AMPK α2:60.7 nM, KDR:3820 nM |
In vitro |
At a concentration of 100 nM, AMPK-IN-3 exhibits inhibition values of 64%, 43%, 41%, and 29% for AMPK(α2), FLT1, JAK1 JH2-pseudokinase, and AMPK(α1), respectively[1].In K562 cells, AMPK-IN-3, when applied at concentrations of 0.195313, 0.78125, 3.125, 12.5, and 50 µM for 2 hours, reduces the level of p-ACC[1]. For a duration of 24, 48, and 72 hours, AMPK-IN-3, within the concentration range of 1-100 µM, demonstrates potent inhibition of cellular AMPK activity without affecting cell viability[1]. |
分子量 | 451.56 |
分子式 | C25H33N5O3 |
CAS No. | 2417674-27-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (110.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AMPK-IN-3 2417674-27-0 Angiogenesis Chromatin/Epigenetic PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors AMPK VEGFR Inhibitor inhibitor inhibit