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Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer
説明 | Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.Parsatuzumab selectively inhibits the interaction between EGFL7 and endothelial cells, and has an inhibitory effect on endothelial growth factor (VEGF).Parsatuzumab has been used in combination with other compounds for a long time. Combined use to study rectal cancer |
In vitro |
EGFL7 is a vascular-restricted extracellular matrix protein that promotes endothelial cell adhesion and survival[2]. Against patient-derived xenograft (PDX) cells, Parsatuzumab inhibits cell proliferation and increases apoptosis after 48 hours[1]. |
In vivo | In several xenograft and genetically engineered murine tumor models, Parsatuzumab (anti-EGFL7) enhances the antiangiogenesis, tumor growth control, and survival associated with antiVEGF monotherapy[1].In mouse models of mantle cell lymphoma (MCL), Parsatuzumab (50 mg/kg; i.v.; 3 times per week) targets EGFL7, inhibits MCL cell growth, and prolongs survival[1]. |
別名 | RG 7414, Anti-EGFL7, MEGF0444A, MEGF-0444A, RO-5490248, M0444A |
分子量 | N/A |
CAS No. | 1312797-14-0 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Parsatuzumab 1312797-14-0 Angiogenesis Tyrosine Kinase/Adaptors VEGFR RG 7414 Anti-EGFL7 MEGF0444A MEGF-0444A RO-5490248 M0444A Inhibitor inhibitor inhibit