store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.
説明 | BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors. |
ターゲット&IC50 | Tie2:1.6 nM (Kd) |
In vitro | BAY-826 is a selective and potent inhibitor of TIE-2 (dissociation constant = 1.6 nM) and binds with similar high affinity to only 4 of 456 tested kinases,namely, TIE-1,DDR1, DDR2, and Serine/threonine-protein kinase 10(LOK) (dissociation constant = 0.9, 0.4, 1.3, and 5.9 nM[1]. |
In vivo | A single oral dose of BAY-826 at 100, 50, or 25 mg/kg effectively inhibits ang-1-induced autophosphorylation of TIE-2 in mouse lungs[1]. |
分子量 | 558.53 |
分子式 | C26H19F5N6OS |
CAS No. | 1448316-08-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (143.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BAY-826 1448316-08-2 Tyrosine Kinase/Adaptors Tie-2 BAY826 BAY 826 Inhibitor inhibitor inhibit