Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
説明 | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM. |
ターゲット&IC50 | TrkA:1 nM, TrkB:1 nM, Tie2:4.7 nM |
In vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM. Which displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1]. |
In vivo | In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%)[1]. |
分子量 | 513.38 |
分子式 | C24H22Cl2N6O3 |
CAS No. | 717899-97-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (243.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CE-245677 717899-97-3 Tyrosine Kinase/Adaptors Tie-2 Trk receptor Inhibitor Tropomyosin related kinase receptor Trk Receptor CE245677 inhibit CE 245677 inhibitor