Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 21,500 |
2 mg | 在庫あり | ¥ 31,500 |
5 mg | 在庫あり | ¥ 45,500 |
10 mg | 在庫あり | ¥ 80,000 |
25 mg | 在庫あり | ¥ 135,500 |
50 mg | お問い合わせ | ¥ 193,500 |
100 mg | お問い合わせ | ¥ 266,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 61,500 |
説明 | EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2). |
ターゲット&IC50 | FGFR1:6 nM, Tie2:4 nM, VEGFR2:2 nM |
In vitro | ACTB-1003 targets cancer mutations via FGFR inhibition FGFR1 (IC50: 6 nM), angiogenesis through inhibition of VEGFR2 (2 nM) and Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). In cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1, ACTB-1003 can markedly and dose-dependently inhibit tumor growth. OPM2 cells harbor the FGFR3 t (4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression. |
In vivo | ACTB-1003 inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. The combination ACTB-1003 with 5-FU or paclitaxel not diminish the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model. |
別名 | ACTB-1003, ACTB1003, ACTB 1003 |
分子量 | 591.53 |
分子式 | C27H26F5N7O3 |
CAS No. | 939805-30-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EOC317 939805-30-8 Angiogenesis Tyrosine Kinase/Adaptors VEGFR Tie-2 FGFR EOC-317 Fibroblast growth factor receptor Vascular endothelial growth factor receptor inhibit Inhibitor ACTB-1003 EOC 317 ACTB1003 ACTB 1003 inhibitor