Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約8-10週間 | ¥ 144,500 |
5 mg | 約8-10週間 | ¥ 356,000 |
10 mg | 約8-10週間 | ¥ 569,500 |
25 mg | 約8-10週間 | ¥ 844,500 |
50 mg | 約8-10週間 | ¥ 1,124,500 |
100 mg | 約8-10週間 | ¥ 1,521,500 |
説明 | BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865. |
In vitro | BI-2493 inhibits the proliferation with IC50 values < 140 nM in Ba/F3 cell lines made dependent on KRAS by transfection of different mutant KRAS oncogenes (e.g., KRAS G12C, KRAS G12D, KRAS G12V)[1]. |
In vivo | BI-2493 (90 mg/kg; gavage) attenuats tumour growth in mice bearing KRAS G12C, G12D, G12V and A146V mutant models, without causing apparent toxicity to the mice[1]. |
分子量 | 461.58 |
分子式 | C24H27N7OS |
CAS No. | 2937344-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (216.65 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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BI-2493 2937344-16-4 GPCR/G Protein MAPK Ras BI2493 BI 2493 Inhibitor inhibitor inhibit