Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-986278 is an orally active and potent hemophosphatidic acid receptor 1 (LPA1) antagonist with Kb values of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively.BMS-986278 may be investigated for use in idiopathic pulmonary fibrosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 133,000 | |||
10 mg | 在庫あり | ¥ 213,000 | |||
25 mg | 在庫あり | ¥ 429,500 | |||
50 mg | 在庫あり | ¥ 682,000 | |||
100 mg | 在庫あり | ¥ 911,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 146,500 |
説明 | BMS-986278 is an orally active and potent hemophosphatidic acid receptor 1 (LPA1) antagonist with Kb values of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively.BMS-986278 may be investigated for use in idiopathic pulmonary fibrosis. |
In vitro | With Kbs of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively, BMS-986278 is a high-affinity LPA1 antagonist. These values were determined in CHO cells overexpressing LPA1[1]. BMS-986278 also antagonizes Lysophosphatidic acid (LPA)-stimulated calcium flux in normal human lung fibroblasts, exhibiting a Kb of 5.8 nM[1]. |
In vivo | In CD1 mice, a single oral administration of BMS-986278 (0.1-10 mg/kg) completely inhibits LPA-stimulated systemic histamine release in a concentration-dependent manner[1]. Furthermore, when administered orally twice daily for 14 days at doses ranging from 3 to 30 mg/kg, BMS-986278 reduces Bleomycin-induced collagen deposition and lung fibrosis in rats[1]. |
分子量 | 445.51 |
分子式 | C22H31N5O5 |
CAS No. | 2170126-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (202.02 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BMS-986278 2170126-74-4 GPCR/G Protein LPA Receptor BMS986278 BMS 986278 Inhibitor inhibitor inhibit