Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 65,500 |
5 mg | 在庫あり | ¥ 158,000 |
10 mg | 在庫あり | ¥ 229,000 |
25 mg | 在庫あり | ¥ 340,000 |
50 mg | 在庫あり | ¥ 457,000 |
100 mg | 在庫あり | ¥ 617,500 |
説明 | Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials. |
In vitro |
Butyzamide (3 μM; 15 minutes) induces phosphorylation of JAK2, STAT3, STAT5, and MAPK in Ba/F3-hMpl cells.[1] Butyzamide (3 μM; 48 hours) induces colony-forming unit-megakaryocyte (CFU-MK) and polyploid megakaryocyte formation in human CD34+ hematopoietic progenitor cells.[1] |
In vivo | Butyzamide (10 mg/kg, 50 mg/kg; oral administration; once daily for 20 days) increases human platelet levels in NOG mice transplanted with human fetal liver-derived CD34+ cells.[1] |
分子量 | 591.55 |
分子式 | C29H32Cl2N2O5S |
CAS No. | 1110767-45-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (751.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Butyzamide 1110767-45-7 Angiogenesis Chromatin/Epigenetic Immunology/Inflammation JAK/STAT signaling Stem Cells JAK Thrombopoietin Receptor Inhibitor inhibitor inhibit