Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 75,500 |
5 mg | 在庫あり | ¥ 183,500 |
10 mg | 在庫あり | ¥ 250,500 |
25 mg | 在庫あり | ¥ 379,000 |
50 mg | 在庫あり | ¥ 512,000 |
100 mg | 在庫あり | ¥ 672,500 |
説明 | C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases. |
In vitro | C004019 induced a robust tau clearance via promoting its ubiquitination-proteasome-dependent proteolysis in HEK293 cells with stable or transient overexpression of human tau (hTau), and in SH-SY5Y that constitutively overexpress hTau.[1] |
In vivo | C004019 induced a robust tau clearance in vivo by intracerebral ventricular infusion. Most importantly, both single-dose and multiple-doses (once per 6 days for a total of 5 times) subcutaneous administration of C004019 remarkably decreased tau levels in the brains of wild-type, hTau-transgenic and 3xTg-AD mice with the improvement of synaptic and cognitive functions.[1] |
分子量 | 1035.29 |
分子式 | C49H70N12O9S2 |
CAS No. | 2417159-57-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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C004019 2417159-57-8 Cytoskeletal Signaling PROTAC Microtubule Associated PROTACs C-004019 C 004019 Inhibitor inhibitor inhibit