Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 88,000 |
5 mg | 在庫あり | ¥ 210,000 |
10 mg | 在庫あり | ¥ 287,000 |
25 mg | 在庫あり | ¥ 424,500 |
50 mg | 在庫あり | ¥ 569,500 |
100 mg | 在庫あり | ¥ 773,500 |
説明 | Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation. |
In vitro | Cbl-b-IN-3, augments the secretion of IL-2 by T-cells when stimulated with either an anti-CD3 antibody alone or in combination with an anti-CD28 antibody [1]. |
分子量 | 537.62 |
分子式 | C30H34F3N5O |
CAS No. | 2573775-59-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Cbl-b-IN-3 2573775-59-2 Ubiquitination E1/E2/E3 Enzyme Inhibitor inhibitor inhibit