Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.
説明 | Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma. |
In vitro | In BT474 cells, Compound C108 (1 μM) shows anti-tumor activity[1]. In G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells, Compound C108 (4 μM) reduces the protein expression of G3BP2 and attenuates ESCC cell metastasis, migration and invasion[2]. |
In vivo | In a mouse xenograft model of breast cancer, compound C108 (1 μM) reduces the proportion of tumor-initiating cells approximately 10-fold[1]. |
分子量 | 270.28 |
分子式 | C15H14N2O3 |
CAS No. | 15533-09-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF:PBS(pH 7.2)(1:6): 0.14 mg/mL
DMF: 1 mg/mL
DMSO: 22.5 mg/mL (83.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Compound C108 15533-09-2 GPCR/G Protein GTPase Compound C-108 Compound C 108 Inhibitor inhibitor inhibit