Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 135,000 | |||
50 mg | 在庫あり | ¥ 192,500 | |||
100 mg | 在庫あり | ¥ 266,500 | |||
500 mg | 在庫あり | ¥ 532,500 |
説明 | COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer. |
ターゲット&IC50 | COX-2:0.84 μM |
In vitro |
COX-2-IN-6 (Compound 10) inhibits human COX-2/COX-1 enzyme and COX-2/COX-1-driven PGE2 synthesis in HEK293 cells, with IC50 of 0.84 μM、>50 μM、0.60 μM and, >50 μM, respectively.[1] COX-2-IN-6 exhibits stability in human or mouse liver microsomes and hepatocytes in vitro. The T1/2 value of human hepatocytes is 3.1 min, and the T1/2 value of mouse hepatocytes is 3.0 min.[1] |
In vivo |
COX-2-IN-6 (Compound 10) (30, 100, 300 mg/kg; oral; single dose; APCmin/mouse model) inhibits adenoma progression and extends survival in the APCmin/+ mouse model.[1] COX-2-IN-6 (10 mg/kg; oral; single dose; APCmin/+ mouse model) exhibits high colonic exposure (>4300 ng/g) and low systemic exposure (<6 ng/mL), C/P distribution ratio > 1200 in 4 hours.[1] |
分子量 | 409.5 |
分子式 | C20H27NO6S |
CAS No. | 2756347-91-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40.95 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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COX-2-IN-6 2756347-91-6 GPCR/G Protein Immunology/Inflammation Neuroscience COX Prostaglandin Receptor Inhibitor inhibitor inhibit