Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 9,000 | |||
100 mg | 在庫あり | ¥ 12,500 | |||
200 mg | 在庫あり | ¥ 14,500 | |||
500 mg | 在庫あり | ¥ 24,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. |
ターゲット&IC50 | CYP3A5:0.206 μM (IC50), CYP3A4:15.6 μM (IC50) |
別名 | Dermovate, Clobetasol 17-propionate, CGP9555, Temovate, CCl 4725 |
分子量 | 466.97 |
分子式 | C25H32ClFO5 |
CAS No. | 25122-46-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 86 mg/mL (184.2 mM)
Ethanol: 16 mg/mL (34.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Clobetasol propionate 25122-46-7 Endocrinology/Hormones Metabolism Glucocorticoid Receptor P450 Dermovate Clobetasol 17-propionate CGP9555 Cytochrome P450 CGP 9555 Inhibitor inhibit dermatoses Clobetasol corticosteroid CYPs Temovate CGP-9555 psoriasis CCl 4725 Clobetasol Propionate inhibitor