Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 48,500 |
5 mg | 在庫あり | ¥ 119,500 |
10 mg | 在庫あり | ¥ 173,000 |
25 mg | 在庫あり | ¥ 266,500 |
50 mg | 在庫あり | ¥ 360,500 |
100 mg | 在庫あり | ¥ 486,500 |
500 mg | 在庫あり | ¥ 975,500 |
説明 | Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis. |
In vivo | Dersalazine sodium (DS) (10 or 30 mg/kg; b.i.d.; rats), when administered for 7 days, showed intestinal anti-inflammatory effects in TNBS-induced colitis; these effects were observed both macroscopically and through the profile of inflammatory mediators (TNF, IL-1β, IL-6, and IL-17). Although the 2 day treatment with DS did not induce intestinal anti-inflammatory effects, it was sufficient to reduce the enhanced IL-17 expression. DS showed beneficial effects on DSS-induced colitis in C57BL/6 mice and reduced colonic pro-inflammatory cytokines IL-1β, IL-6, and IL-17.[2] |
別名 | Dersalazine Free Base |
分子量 | 600.67 |
分子式 | C35H32N6O4 |
CAS No. | 188913-58-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1mg/ml (insoluble)
You can also refer to dose conversion for different animals. 詳細
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Dersalazine 188913-58-8 Immunology/Inflammation Others IL Receptor Platelet aggregation Dersalazine Free Base Inhibitor inhibitor inhibit